Relationship of human papillomavirus with diseases of the oral cavity
Med Clin (Barc). 2019 Aug 16;153(4):157-164.
doi: 10.1016/j.medcli.2019.02.027.
Epub 2019 May 17.
[Article in
English,
Spanish]
Affiliations
- 1 Facultad de Medicina y Ciencias de la Salud, Odontología, Universidad de Barcelona, Barcelona, España.
- 2 Servicio de oncología médica, Xarxa Sanitària i Social de Santa Tecla, Tarragona, España.
- 3 Unidad Medicina Bucal, Departamento de Odontoestomatología, Facultad de de Medicina y Ciencias de la Salud, Odontología, Universitat de Barcelona, Oral Health and Masticatory System Group, Institut d'Investigació Biomédica de Bellvitge (Idibell), l'Hospitalet de Llobregat, Barcelona, España. Electronic address: enricjanesalas@ub.edu.
Abstract
Over the last few decades, the human papillomavirus (HPV) infection has emerged as a new epidemic and become a health issue due to its involvement in several cancers affecting the cervix, the anogenital region and the oropharynx. In this review, we aim to understand and explain the distinctive features of HPV-related oropharyngeal squamous cell carcinoma based on its epidemiological data, risk factors, specific topography, HPV subtypes most frequently involved, HPV-status diagnosis, clinical behaviour, prognosis, treatment, and preventive measures. In addition, the relationship of HPV with the development of other head and neck carcinomas and benign lesions of the oral cavity will also be discussed.
Keywords:
Carcinoma escamoso de cabeza y cuello; Carcinoma escamoso de orofaringe; Head and neck squamous cell carcinoma; Human papillomavirus; Oropharyngeal squamous cell carcinoma; Virus del papiloma humano.
Copyright © 2019 Elsevier España, S.L.U. All rights reserved.
MeSH terms
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Carcinoma, Squamous Cell / epidemiology
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Carcinoma, Squamous Cell / therapy
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Carcinoma, Squamous Cell / virology*
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Female
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Head and Neck Neoplasms / epidemiology
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Head and Neck Neoplasms / virology
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Humans
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Incidence
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Male
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Oropharyngeal Neoplasms / epidemiology
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Oropharyngeal Neoplasms / therapy
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Oropharyngeal Neoplasms / virology*
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Papillomaviridae* / classification
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Papillomaviridae* / genetics
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Papillomaviridae* / isolation & purification
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Papillomaviridae* / pathogenicity
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Papillomavirus Infections / complications*
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Papillomavirus Infections / epidemiology
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Papillomavirus Infections / therapy
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Prevalence
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Risk Factors
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Sex Factors
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Spain / epidemiology