Synthesis, identification and application of the novel metal-organic framework Fe3O4@PAA@ZIF-8 for the drug delivery of ciprofloxacin and investigation of antibacterial activity

Abstract

Today, metal-organic frameworks (MOFs) for the release of drugs have been studied extensively. In this research, we have investigated the novel magnetic framework including Fe₃O₄@PAA@ZIF-8 for the delivery of ciprofloxacin (CIP) antibiotic. Moreover, the antibacterial activity of Fe₃O₄@PAA@ZIF-8 and Fe₃O₄@PAA@ZIF-8@CIP screened against Staphylococcus aureus ( S. aureus) and Escherichia coli ( E. coli) bacteria. The structure of the nano carrier, as well as the encapsulation of the drug in the framework was confirmed by the Fourier-transform infrared spectroscopy (FT-IR), Ultraviolet-visible spectroscopy (UV-Vis), Energy-dispersive X-ray spectroscopy (EDX), X-ray crystallography (XRD), Scanning electron microscope (SEM) and Brunauer-Emmett-Teller (BET) analysis. The results of this study showed that 93% of the CIP was loaded on the synthesized framework. Drug release was done at pH: 7.4 and pH: 5 within 2 d, resulting about 73% release of the drug.

Keywords: Ciprofloxacin; FeO@PAA@ZIF-8; MOFs; antibacterial activity; drug delivery; zeolite imidazole.