Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report

Ann Hepatol. 2019 Jan-Feb;18(1):263-268. doi: 10.5604/01.3001.0012.7936.


Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

Keywords: Amyloidosis; Hepatocellular adenoma; Interleukin-6; Systemic symptoms; Unicentric plasma cell type Castleman disease.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoma, Liver Cell / complications*
  • Adenoma, Liver Cell / diagnosis
  • Adenoma, Liver Cell / surgery
  • Adult
  • Biopsy, Large-Core Needle
  • Castleman Disease / complications*
  • Castleman Disease / diagnosis
  • Diagnosis, Differential
  • Hepatectomy
  • Humans
  • Liver Neoplasms / complications*
  • Liver Neoplasms / diagnosis
  • Liver Neoplasms / surgery
  • Magnetic Resonance Imaging
  • Male
  • Tomography, X-Ray Computed