Evolving screening and surveillance techniques for Barrett's esophagus

World J Gastroenterol. 2019 May 7;25(17):2045-2057. doi: 10.3748/wjg.v25.i17.2045.


Barrett's esophagus (BE) is a change in the esophageal lining and is known to be the major precursor lesion for most cases of esophageal adenocarcinoma (EAC). Despite an understanding of its association with BE for many years and the falling incidence rates of squamous cell carcinoma of the esophagus, the incidence for EAC continues to rise exponentially. In association with this rising incidence, if the delay in diagnosis of EAC occurs after the onset of symptoms, then the mortality at 5 years is greater than 80%. Appropriate diagnosis and surveillance strategies are therefore vital for BE. Multiple novel optical technologies and other advanced approaches are being utilized to assist in making screening and surveillance more cost effective. We review the current guidelines and evolving techniques that are currently being evaluated.

Keywords: Barrett’s esophagus; Endoscopy; Imaging; Narrow band imaging; New techniques; Radiofrequency ablation; Screening; Surveillance.

Publication types

  • Review

MeSH terms

  • Adenocarcinoma / diagnosis
  • Barrett Esophagus / diagnosis*
  • Barrett Esophagus / epidemiology
  • Biomarkers, Tumor / metabolism
  • Breath Tests
  • Carcinoma, Squamous Cell / diagnosis
  • Disease Progression
  • Early Detection of Cancer / methods*
  • Endoscopy
  • Esophageal Neoplasms / diagnosis
  • Esophagoscopy
  • Humans
  • Incidence
  • Lasers
  • Mass Screening / methods*
  • Practice Guidelines as Topic
  • Precancerous Conditions / diagnosis
  • Prognosis
  • Radiofrequency Ablation
  • Tomography, Optical Coherence


  • Biomarkers, Tumor

Supplementary concepts

  • Adenocarcinoma Of Esophagus