Association of Severe Influenza Virus Infections With CD226 (DNAM-1) Variants

J Infect Dis. 2019 Aug 30;220(7):1162-1165. doi: 10.1093/infdis/jiz270.


Natural killer (NK)-cell response against influenza viruses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1). We analyzed whether particular CD226 variants were associated with influenza disease severity. Comparison between 145 patients hospitalized with severe influenza at intensive care units (ICU) with 139 matched influenza-positive outpatients showed that presence of the rs763362 G allele (GG, AG) was associated with occurrence of severe influenza infections (P = .0076). Also, a higher frequency of rs727088 G and rs763361 T alleles was observed in the ICU group. Thus, CD226 variants may contribute to the severity of influenza virus disease.

Keywords: CD226; CD226 and influenza; CD226 variants and disease severity; severe influenza.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Alleles
  • Antigens, Differentiation, T-Lymphocyte / genetics*
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Gene Frequency / genetics
  • Genetic Predisposition to Disease
  • Hospitalization
  • Humans
  • Infant
  • Infant, Newborn
  • Influenza, Human / genetics*
  • Influenza, Human / virology
  • Intensive Care Units
  • Killer Cells, Natural / metabolism
  • Male
  • Middle Aged
  • Orthomyxoviridae*
  • Outpatients
  • Polymorphism, Single Nucleotide / genetics*
  • Retrospective Studies
  • Severity of Illness Index*
  • Young Adult


  • Antigens, Differentiation, T-Lymphocyte
  • CD226 antigen