The effect of fluoride and calcium on spinal bone mineral content: a controlled, prospective (3 years) study

Calcif Tissue Int. 1987 Jun;40(6):315-7. doi: 10.1007/BF02556692.


Daily treatment with 30 mg of sodium fluoride (NaF) and 1 g of calcium over a 3-year period increased the bone mineral content (BMC) in the spines of women (n = 25) with osteoporosis. Determination of the BMC was followed with dual photon absorptiometry (137Cs-241Am) in the third lumbar vertebra. No increase in BMC was found with only 10 mg sodium fluoride in combination with calcium (n = 25), with calcium alone (n = 25), or with placebo (n = 25). No serious side effects were registered. There was, however, minor gastrointestinal distress in one-fifth of the patients taking 30 mg NaF daily.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Calcium / therapeutic use*
  • Clinical Trials as Topic
  • Female
  • Humans
  • Middle Aged
  • Minerals / metabolism*
  • Osteoporosis / drug therapy*
  • Osteoporosis / metabolism
  • Prospective Studies
  • Sodium Fluoride / adverse effects
  • Sodium Fluoride / therapeutic use*
  • Spine / metabolism*


  • Minerals
  • Sodium Fluoride
  • Calcium