The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless

Cell. 1987 Aug 14;50(4):649-57. doi: 10.1016/0092-8674(87)90038-9.


We have isolated the Drosophila melanogaster homolog (Dint-1) of int-1, a conserved cellular oncogene implicated in viral mammary tumorigenesis in mice. The deduced Dint-1 protein sequence contains 468 amino acids and starts with a hydrophobic leader; it is 54% identical to the int-1 sequence, and all 23 cysteine residues are conserved. The putative Drosophila protein has an extra sequence of 85 amino acids, encoded on an additional exon. Dint-1 is expressed throughout development, but transcripts are barely detectable in adult flies. Hybridization in situ to embryos reveals a segmented pattern of expression. We show that Dint-1 and the segment polarity gene wingless are identical and map to the same location. The sequence of the gene suggests that the Dint-1/wingless protein functions in morphogenesis as a signal in cell-cell communication.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • DNA / genetics
  • Drosophila melanogaster / embryology
  • Drosophila melanogaster / genetics*
  • Gene Expression Regulation
  • Genes*
  • Insect Hormones / genetics*
  • Insect Hormones / physiology
  • Larva / analysis
  • Larva / ultrastructure
  • Mammary Neoplasms, Experimental / genetics
  • Mice / embryology
  • Mice / genetics
  • Morphogenesis
  • Proto-Oncogene Proteins / genetics
  • Proto-Oncogenes
  • Sequence Homology, Nucleic Acid
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins*


  • Insect Hormones
  • Proto-Oncogene Proteins
  • Wnt Proteins
  • Wnt1 Protein
  • Zebrafish Proteins
  • DNA

Associated data

  • GENBANK/M17230