Persistent Disruption of Brain Connectivity after Sports-Related Concussion in a Female Athlete

J Neurotrauma. 2019 Nov 15;36(22):3164-3171. doi: 10.1089/neu.2019.6377. Epub 2019 Aug 1.


Structural and functional connectivity (FC) after sports-related concussion (SRC) may remain altered in adolescent athletes despite symptom resolution. Little is known, however, about how alterations in structural connectivity and FC co-present in female athletes whose symptom recovery tends to be prolonged. Despite resolution of symptoms, one month after her second SRC, an 18-year-old female athlete had decreased structural connectivity in the corpus callosum and cingulum, with altered FC near those regions, compared with other SRC and orthopedically injured athletes. Findings show persistent effects of SRC on advanced brain imaging and the possibility of greater vulnerability of white matter tracts in females.

Keywords: female athlete; functional connectivity; sports-related concussion; structural connectivity; traumatic brain injury.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Brain / diagnostic imaging
  • Brain / physiopathology*
  • Brain Concussion / diagnostic imaging
  • Brain Concussion / physiopathology*
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Nerve Net / diagnostic imaging
  • Nerve Net / physiopathology*
  • Soccer / injuries*