Anti-dsDNA and complement profiles as prognostic guides in systemic lupus erythematosus

Arthritis Rheum. 1979 Mar;22(3):226-35. doi: 10.1002/art.1780220304.


Antibodies to dsDNA, tested with circular DNA in the Farr assay, are specific for systemic lupus erythematosus. A longitudinal study showed a clear relation between the clinical state, the anti-dsDNA titer (expressed in units), and the C1q and C3 levels: when anti-dsDNA levels remained high, no exacerbations were observed. A sharp drop in anti-dsDNA, usually preceded by a rise, was related to a serious exacerbation. Only during the exacerbation when both C1q and C3 were very low was renal involvement seen.

MeSH terms

  • Antibodies, Antinuclear* / analysis
  • Centrifugation
  • Chemical Precipitation
  • Complement C1* / analysis
  • Complement C2* / analysis
  • DNA / immunology*
  • DNA, Circular
  • DNA, Viral
  • Humans
  • Kidney / physiopathology
  • Kidney Function Tests
  • Lupus Erythematosus, Systemic / diagnosis*
  • Lupus Erythematosus, Systemic / immunology
  • Lupus Erythematosus, Systemic / physiopathology
  • Prognosis


  • Antibodies, Antinuclear
  • Complement C1
  • Complement C2
  • DNA, Circular
  • DNA, Viral
  • DNA