Clinical Efficacy of Oligofructans from Ophiopogon japonicus in Reducing Atopic Dermatitis Flare-ups in Caucasian Patients

Acta Derm Venereol. 2019 Sep 1;99(10):858-864. doi: 10.2340/00015555-3224.


Atopic dermatitis is a chronic relapsing inflammatory skin disease affecting 15-20% children and 2-10% adults worldwide. Topical treatments include corticosteroids and calcineurin inhibitors, despite frequently observed adverse events such as skin atrophy, itching and burning sensations. Good alternatives that can prolong disease relief in between flare-ups are therefore needed. We conducted a randomized, single-blind, placebo-controlled, multicenter clinical trial in a Caucasian cohort of 90 children and 144 adults with mild-to-moderate atopic dermatitis that applied tested products twice daily for 60 days. A natural active from Ophiopogon japonicus, that improves atopic dermatitis symptoms in vivo, was successful in reducing the SCORing of Atopic Dermatitis (SCORAD), including erythema, pruritus and body surface area in both cohorts. The active also improved patient's quality of life and significantly reduced the number of patients relapsing compared to placebo. We conclude that this treatment could be an effective solution to help control the disease in between flare-ups.

Keywords: Ophiopogon japonicus; SCORAD; clinical trial: oligofructans; quality of life; relief; atopic dermatitis.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child, Preschool
  • Dermatitis, Atopic / diagnosis
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / ethnology
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / isolation & purification
  • Dermatologic Agents / therapeutic use*
  • Female
  • France
  • Fructans / adverse effects
  • Fructans / isolation & purification
  • Fructans / therapeutic use*
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Ophiopogon* / chemistry
  • Plant Extracts / adverse effects
  • Plant Extracts / isolation & purification
  • Plant Extracts / therapeutic use*
  • Poland
  • Quality of Life
  • Recurrence
  • Remission Induction
  • Severity of Illness Index
  • Single-Blind Method
  • Time Factors
  • Treatment Outcome
  • White People
  • Young Adult


  • Dermatologic Agents
  • Fructans
  • Plant Extracts