Extracellular polysaccharide produced by Chlorella vulgaris - Chemical characterization and anti-asthmatic profile

Int J Biol Macromol. 2019 Aug 15:135:1-11. doi: 10.1016/j.ijbiomac.2019.05.104. Epub 2019 May 20.


Microalgae are the lowest plant organisms producing a wide range of metabolites that make them interesting organisms for industrial applications. Cultivation of green microalgal species Chlorella vulgaris resulted a significant production of extracellular polysaccharide (EPS). Preliminary chemico-spectroscopic studies on EPS revealed its molecular profile, a complex primary structure consisting of six monosaccharide units occurring in both furano and pyrano forms, a high sugar binding variability and the presence of partially methylated derivatives of some sugar constituents. Biological activity tests showed that EPS caused significant bronchodilatory, anti-inflammatory and antitussive effects in test animals. Chlorella EPS appears to be a promising agent for the prevention of chronic airway inflammation, which is the basic pathogenic mechanism of many respiratory diseases, including bronchial asthma.

Keywords: Anti-asthmatic effect; Extracellular polysaccharide; Green microalgae.

MeSH terms

  • Allergens
  • Animals
  • Anti-Asthmatic Agents / chemistry*
  • Anti-Asthmatic Agents / metabolism
  • Anti-Asthmatic Agents / pharmacology*
  • Bronchial Hyperreactivity / drug therapy
  • Bronchial Hyperreactivity / immunology
  • Bronchial Hyperreactivity / physiopathology
  • Chemical Phenomena
  • Chlorella vulgaris / metabolism*
  • Cytokines / metabolism
  • Disease Models, Animal
  • Extracellular Space / metabolism
  • Guinea Pigs
  • Inflammation Mediators / metabolism
  • Male
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / immunology
  • Muscle, Smooth / metabolism
  • Polysaccharides / biosynthesis
  • Polysaccharides / chemistry*
  • Polysaccharides / pharmacology*
  • Spectrum Analysis


  • Allergens
  • Anti-Asthmatic Agents
  • Cytokines
  • Inflammation Mediators
  • Polysaccharides