Healthcare is facing a world of change. New regulations, rapid advances in information technology, shifts in payment from volume to value, consumer demands for better access to care, increased public scrutiny of outcomes, patient safety concerns, and business consolidation all add increasing degrees of difficulty to the work that healthcare leaders do. Effective management of a diverse workforce can make a significant impact on all of these challenges.This article covers four aspects of workforce management: talent, leadership, technology, and culture. Each is described, along with tactics to address it. The recommendations are based on both my research of human capital management and my experience as a senior human resource officer and healthcare executive, now with the nation's third-largest nonprofit health system, Catholic Health Initiatives.