Coat flexibility in the secretory pathway: a role in transport of bulky cargoes

Curr Opin Cell Biol. 2019 Aug;59:104-111. doi: 10.1016/ Epub 2019 May 21.


Membrane trafficking in eukaryotic cells is a highly dynamic process, which needs to adapt to a variety of cargo proteins. The COPII coat mediates ER export of thousands of proteins with a wide range of sizes by generating coated membrane vesicles that incapsulate cargo. The process of assembly and disassembly of COPII, regulated by GTP hydrolysis, is a major determinant of the size and shape of transport carriers. Here, we analyse our knowledge of the COPII coat architecture and it assembly/disassembly dynamics, and link coat flexibility to the role of COPII in transport of large cargoes. We propose a common mechanism of action of regulatory factors that modulate COPII GTP hydrolysis cycle to promote budding.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • COP-Coated Vesicles / metabolism
  • Endoplasmic Reticulum / metabolism
  • Humans
  • Models, Biological
  • Protein Transport
  • Secretory Pathway*