Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst - A review on its mechanistic aspects

Complement Ther Med. 2019 Jun;44:68-82. doi: 10.1016/j.ctim.2019.03.016. Epub 2019 Mar 30.

Abstract

Bacopa monnieri (L.) - (BM) is a perennial, creeping herb which is widely used in traditional ayurvedic medicine as a neural tonic to improve intelligence and memory. Research into the biological effects of this plant has burgeoned in recent years, promising its neuroprotective and memory boosting ability among others. In this context, an extensive literature survey allows an insight into the participation of numerous signaling pathways and oxidative mechanism involved in the mitigation of oxidative stress, along with other indirect mechanisms modulated by bioactive molecules of BM to improve the cognitive action by their synergistic potential and cellular multiplicity mechanism. This multi-faceted review describes the novel mechanisms that underlie the unfounded but long flaunted promises of BM and thereby direct a way to harness this acquired knowledge to develop innovative approaches to manipulate its intracellular pathways.

Keywords: Bacopa monnieri; Bacosides; Brahmi; Cognitive health; Memory booster; Neuroprotection.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacopa / chemistry*
  • Cognition / drug effects*
  • Humans
  • Medicine, Ayurvedic / methods
  • Memory / drug effects
  • Neuroprotective Agents / pharmacology*
  • Neuroprotective Agents / therapeutic use*
  • Oxidative Stress / drug effects
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use*

Substances

  • Neuroprotective Agents
  • Plant Extracts