Grey and white matter substrates of action naming

Yu Akinina; O Dragoy; M V Ivanova; E V Iskra; O A Soloukhina; A G Petryshevsky; O N Fedinа; A U Turken; V M Shklovsky; N F Dronkers

doi:10.1016/j.neuropsychologia.2019.05.015

Grey and white matter substrates of action naming

Neuropsychologia. 2019 Aug:131:249-265. doi: 10.1016/j.neuropsychologia.2019.05.015. Epub 2019 May 23.

Authors

Yu Akinina¹, O Dragoy², M V Ivanova³, E V Iskra⁴, O A Soloukhina⁵, A G Petryshevsky⁶, O N Fedinа⁷, A U Turken⁸, V M Shklovsky⁶, N F Dronkers⁹

Affiliations

¹ National Research University Higher School of Economics, Center for Language and Brain, 21/4 Staraya Basmannaya Street, Office 510, 105066, Moscow, Russia; University of Groningen, Graduate School for the Humanities, P.O. Box 716, NL-9700, AS Groningen, Groningen, the Netherlands. Electronic address: jakinina@hse.ru.
² National Research University Higher School of Economics, Center for Language and Brain, 21/4 Staraya Basmannaya Street, Office 510, 105066, Moscow, Russia; Federal Center for Cerebrovascular Pathology and Stroke, Department of Medical Rehabilitation, 1/10 Ostrovityanova Street, 117342, Moscow, Russia.
³ National Research University Higher School of Economics, Center for Language and Brain, 21/4 Staraya Basmannaya Street, Office 510, 105066, Moscow, Russia; University of California, Berkeley, Dept. of Psychology, 2121 Berkeley Way, 94704, Berkeley, CA, USA; Center for Aphasia and Related Disorders, VA Northern California Health Care System, 150 Muir Road 126R, 94553, Martinez, CA, USA.
⁴ National Research University Higher School of Economics, Center for Language and Brain, 21/4 Staraya Basmannaya Street, Office 510, 105066, Moscow, Russia; Center for Speech Pathology and Neurorehabilitation, 20 Nikoloyamskaya Street, 109240, Moscow, Russia.
⁵ National Research University Higher School of Economics, Center for Language and Brain, 21/4 Staraya Basmannaya Street, Office 510, 105066, Moscow, Russia.
⁶ Center for Speech Pathology and Neurorehabilitation, 20 Nikoloyamskaya Street, 109240, Moscow, Russia.
⁷ Center for Speech Pathology and Neurorehabilitation, 20 Nikoloyamskaya Street, 109240, Moscow, Russia; Medicine and Nuclear Technology Ltd., 1/133 Akademika Kurchatova Street, 123182, Moscow, Russia.
⁸ Center for Aphasia and Related Disorders, VA Northern California Health Care System, 150 Muir Road 126R, 94553, Martinez, CA, USA.
⁹ University of California, Berkeley, Dept. of Psychology, 2121 Berkeley Way, 94704, Berkeley, CA, USA; Center for Aphasia and Related Disorders, VA Northern California Health Care System, 150 Muir Road 126R, 94553, Martinez, CA, USA; University of California, Davis, Dept. of Neurology, Sacramento, CA, USA.

PMID: 31129278
PMCID: PMC6650369
DOI: 10.1016/j.neuropsychologia.2019.05.015

Abstract

Despite a persistent interest in verb processing, data on the neural underpinnings of verb retrieval are fragmentary. The present study is the first to analyze the contributions of both grey and white matter damage affecting verb retrieval through action naming in stroke. We used voxel-based lesion-symptom mapping (VLSM) with an action naming task in 40 left-hemisphere stroke patients. Within the grey matter, we revealed the critical involvement of the left precentral and inferior frontal gyri, insula, and parts of basal ganglia. An overlay of white matter tract probability masks on the VLSM lesion map revealed involvement of left-hemisphere long and short association tracts with terminations in the frontal areas; and several projection tracts. The involvement of these structures is interpreted in the light of existing picture naming models, semantic control processes, and the embodiment cognition framework. Our results stress the importance of both cortico-cortical and cortico-subcortical networks of language processing.

Keywords: Aphasia; Picture naming; VLSM; Verbs; White-matter tracts.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Adult
Aged
Aphasia / diagnostic imaging*
Aphasia / etiology
Brain / diagnostic imaging*
Female
Gray Matter / diagnostic imaging*
Humans
Language
Language Tests
Magnetic Resonance Imaging
Male
Middle Aged
Speech / physiology*
Stroke / complications
Stroke / diagnostic imaging
Vocabulary*
White Matter / diagnostic imaging*

Grants and funding

R01 DC016345/DC/NIDCD NIH HHS/United States