cDC1s: New Orchestrators of Tissue Innate Immunity

Trends Immunol. 2019 Jul;40(7):559-561. doi: 10.1016/ Epub 2019 May 24.


Type-I conventional dendritic cells (cDC1s) are key in inducing adaptive immunity. Using single-cell sequencing, Ginhoux and colleagues (Immunity 2019;50:1069-1083.e8) find that a subset of activated cDC1s in bacteria-infected skin is critical for neutrophil recruitment via the production of VEGF-α. These results reveal a crucial function for cDC1s beyond antigen presentation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Antigen Presentation
  • Bacterial Infections*
  • Dendritic Cells
  • Humans
  • Immunity, Innate
  • Neutrophils*