Lactate jump-starts mTORC1 in cancer cells

EMBO Rep. 2019 Jun;20(6):e48302. doi: 10.15252/embr.201948302. Epub 2019 May 27.

Abstract

The kinase mammalian target of rapamycin (mTOR) is a major regulatory hub that senses and integrates nutrient, energy, and growth factor inputs to promote cell growth. In this issue of EMBO Reports, Byun et al [1] report that high intracellular levels of lactate activate mTORC1 in KRAS transformed cells independently of a growth factor input. This suggests a mechanism for how mTORC1 can be co‐opted to support oncogenic growth and proliferation.

Publication types

  • Comment

MeSH terms

  • Cytoplasm
  • Lactic Acid*
  • Mechanistic Target of Rapamycin Complex 1
  • Proto-Oncogene Proteins p21(ras)*
  • Signal Transduction

Substances

  • Lactic Acid
  • Mechanistic Target of Rapamycin Complex 1
  • Proto-Oncogene Proteins p21(ras)