A flexible and multifunctional metal-organic framework as a matrix for analysis of small molecules using laser desorption/ionization mass spectrometry

Wen Ma; Shuting Xu; Wanpeng Ai; Cheng Lin; Yu Bai; Huwei Liu

doi:10.1039/c9cc02611h

A flexible and multifunctional metal-organic framework as a matrix for analysis of small molecules using laser desorption/ionization mass spectrometry

Chem Commun (Camb). 2019 Jun 11;55(48):6898-6901. doi: 10.1039/c9cc02611h.

Authors

Wen Ma¹, Shuting Xu, Wanpeng Ai, Cheng Lin, Yu Bai, Huwei Liu

Affiliation

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Institute of Analytical Chemistry, Peking University, Beijing 100871, China. yu.bai@pku.edu.cn.

PMID: 31134988
DOI: 10.1039/c9cc02611h

Abstract

A variety of functional metal-organic frameworks (MOFs) were prepared via a universal method and served as matrices in small molecule analysis using laser desorption/ionization mass spectrometry. Among them, cysteine-MOF was found to be a multifunctional composite as an excellent matrix and an efficient adsorbent for N-glycans due to its high hydrophilicity, low background interference and unique size-exclusion effect.