"Miliacin encapsulated by polar lipids stimulates cell proliferation in hair bulb and improves telogen effluvium in women"

J Cosmet Dermatol. 2020 Feb;19(2):485-493. doi: 10.1111/jocd.12998. Epub 2019 May 28.


Background: Miliacin, the main triterpenoid from millet, is known to stimulate keratinocyte metabolism and proliferation. Polar lipids are able to form vesicles with active compounds and to improve their bioavailability.

Objectives: We aimed to demonstrate potential benefits of a solution of miliacin encapsulated within polar lipids (MePL) on telogen effluvium prevention and hair condition in women.

Methods: After preliminary cell proliferation studies, a placebo-controlled, multicentric, randomized, double-blind trial was performed on sixty-five nonmenopausal women affected by telogen effluvium, to assess the efficacy of a 12-week oral supplementation with MePL. Telogen and anagen densities were determined by phototrichogram analysis. Scalp dryness and hair brightness were clinically evaluated using a Likert scale.

Results: MePL further enhanced cell proliferation in hair bulb from human scalp than miliacin alone. Compared to the placebo treatment, MePL supplementation significantly reduced telogen density after 12 weeks of treatment. An increase of anagen density was observed in both groups, although there was no significant difference between the two treatments. Scalp dryness was more decreased in the MePL group than in the placebo group. A better improvement of hair brightness was also observed after 12 weeks of supplementation with MePL.

Conclusion: Twelve weeks of MePL supplementation significantly reduced the hair density in the telogen phase and, in parallel, improved scalp dryness and hair condition. These effects could be linked to MePL activity on cell proliferation in hair bulb. MePL is an original association of plant extract that could help to prevent and/or limit hair loss in women.

Keywords: cell culture; cosmeceuticals; female pattern hair loss; hair disorders; hair treatment.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Adult
  • Alopecia / drug therapy*
  • Alopecia / pathology
  • Cell Proliferation / drug effects
  • Double-Blind Method
  • Drug Carriers / chemistry*
  • Female
  • Hair Follicle / drug effects*
  • Hair Follicle / pathology
  • Humans
  • Lipids / chemistry*
  • Middle Aged
  • Scalp / drug effects
  • Tissue Culture Techniques
  • Treatment Outcome
  • Triterpenes / administration & dosage*


  • Drug Carriers
  • Lipids
  • Triterpenes
  • miliacin