Impact of different intraoperative CO2 pressure levels (8 and 15 mmHg) during laparoscopic hysterectomy performed due to benign uterine pathologies on postoperative pain and arterial pCO2 : a prospective randomised controlled clinical trial

BJOG. 2019 Sep;126(10):1276-1285. doi: 10.1111/1471-0528.15826.

Abstract

Objective: To compare the effects of two different intraoperative CO2 pressures (8 and 15 mmHg) during laparoscopic hysterectomy for benign uterine pathologies in terms of postoperative abdominal and shoulder pain, laparoscopy-mediated vegetative alterations, pain medication requirement, arterial CO2 pressure (pCO2 ), surgical parameters, and safety.

Design: Prospective randomised controlled study.

Setting: German university hospital.

Population: Female patients undergoing laparoscopic hysterectomy for benign uterine pathologies.

Methods: Patients were randomised to a standard pressure (SP; 15 mmHg, control) or low-pressure (LP; 8 mmHg, experimental) group.

Main outcome measures: Primary outcomes were postoperative abdominal and shoulder pain intensities, measured via numeric rating scale (NRS) and vegetative parameters (fatigue, nausea, vomiting, bloating) at 3, 24, and 48 hours postoperatively. Secondary outcomes were pain medication requirement (mg) and arterial pCO2 (mmHg). Surgical parameters and intra- and postoperative complications were also recorded.

Results: In total, 178 patients were included. Patients in the LP group (n = 91) showed significantly lower postoperative abdominal and shoulder pain scores, fewer vegetative alterations, lower pain medication requirements, a shorter postoperative hospitalization, and lower intra- and postoperative arterial pCO2 values compared with the SP group (n = 87; P ≤ 0.01). No differences in intra- and postoperative complications were observed between groups.

Conclusions: Low-pressure laparoscopy seems to be an effective and safe technique for the reduction of postoperative pain and laparoscopy-induced metabolic and vegetative alterations following laparoscopic hysterectomy for benign indications.

Tweetable abstract: Low-pressure laparoscopy seems to be an effective and safe technique for reduction of pain following laparoscopic hysterectomy.

Keywords: Benign uterine disease; hysterectomy; laparoscopy; low-pressure laparoscopy; postoperative pain.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Abdominal Pain / blood
  • Abdominal Pain / etiology*
  • Abdominal Pain / physiopathology
  • Adult
  • Aged
  • Carbon Dioxide / blood*
  • Female
  • Humans
  • Hysterectomy* / adverse effects
  • Intraoperative Complications
  • Laparoscopy* / adverse effects
  • Middle Aged
  • Monitoring, Intraoperative
  • Pain Measurement
  • Pain, Postoperative / blood
  • Pain, Postoperative / etiology*
  • Pain, Postoperative / physiopathology
  • Prospective Studies
  • Shoulder Pain / blood
  • Shoulder Pain / etiology*
  • Shoulder Pain / physiopathology
  • Treatment Outcome
  • Uterine Diseases / pathology
  • Uterine Diseases / surgery*
  • Ventilation-Perfusion Ratio

Substances

  • Carbon Dioxide