Lactose intolerance, lactose malabsorption and genetic predisposition to adult-type hypolactasia in patients after restorative proctocolectomy

Acta Biochim Pol. 2019 May 28;66(2):173-175. doi: 10.18388/abp.2018_2730.


This study provides up-to-date findings on lactose malabsorption, lactose intolerance and genetic predisposition to adult-type hypolactasia in 72 patients after restorative proctocolectomy (RPC). The lactose malabsorption was assessed by hydrogen-methane breath test. Genetic predisposition to adult-type hypolactasia was assessed by detecting -13910T/C polymorphism in the lactase gene. Lactose intolerance was more frequent in UC (ulcerative colitis) patients than FAP (familial adenomatous polyposis) patients (77.5% vs. 55.2%; p=0.01). The C/C genotype of the lactase gene was observed in 39.1% subjects with no significant difference between UC and FAP patients. Lactose malabsorption occurred in 10.1% of subjects and almost only in patients with genetic predisposition, with the same frequency in UC and FAP patients.

MeSH terms

  • Adenomatous Polyposis Coli / surgery*
  • Adult
  • Aged
  • Aged, 80 and over
  • Breath Tests
  • Colitis, Ulcerative / surgery*
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Lactase / deficiency*
  • Lactase / genetics
  • Lactose Intolerance / etiology*
  • Lactose Intolerance / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Genetic
  • Proctocolectomy, Restorative / adverse effects*
  • Self Report
  • Young Adult


  • Lactase

Supplementary concepts

  • Lactose Intolerance, Adult Type