The re-emergence of highly pathogenic avian influenza H7N9 viruses in humans in mainland China, 2019

Euro Surveill. 2019 May;24(21):1900273. doi: 10.2807/1560-7917.ES.2019.24.21.1900273.

Abstract

After no reported human cases of highly pathogenic avian influenza (HPAI) H7N9 for over a year, a case with severe disease occurred in late March 2019. Among HPAI H7N9 viral sequences, those recovered from the case and from environmental samples of a poultry slaughtering stall near their home formed a distinct clade from 2017 viral sequences. Several mutations possibly associated to antigenic drift occurred in the haemagglutinin gene, potentially warranting update of H7N9 vaccine strains.

Keywords: A(H7N9); Highly pathogenic avian influenza virus; Human case; Phylogenetic analysis.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • China / epidemiology
  • Communicable Diseases, Emerging / epidemiology
  • Disease Outbreaks
  • Hemagglutinin Glycoproteins, Influenza Virus / genetics
  • Humans
  • Influenza A Virus, H7N9 Subtype / genetics
  • Influenza A Virus, H7N9 Subtype / isolation & purification*
  • Influenza in Birds / virology*
  • Influenza, Human / diagnosis
  • Influenza, Human / epidemiology*
  • Influenza, Human / virology*
  • Neuraminidase / genetics*
  • Neuraminidase / metabolism
  • Phylogeny
  • Pneumonia / diagnostic imaging
  • Polymerase Chain Reaction
  • Poultry / virology
  • Pulmonary Emphysema / diagnostic imaging
  • Tomography, X-Ray Computed

Substances

  • Hemagglutinin Glycoproteins, Influenza Virus
  • Neuraminidase