Abstract
After no reported human cases of highly pathogenic avian influenza (HPAI) H7N9 for over a year, a case with severe disease occurred in late March 2019. Among HPAI H7N9 viral sequences, those recovered from the case and from environmental samples of a poultry slaughtering stall near their home formed a distinct clade from 2017 viral sequences. Several mutations possibly associated to antigenic drift occurred in the haemagglutinin gene, potentially warranting update of H7N9 vaccine strains.
Keywords:
A(H7N9); Highly pathogenic avian influenza virus; Human case; Phylogenetic analysis.
MeSH terms
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Animals
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China / epidemiology
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Communicable Diseases, Emerging / epidemiology
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Disease Outbreaks
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Hemagglutinin Glycoproteins, Influenza Virus / genetics
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Humans
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Influenza A Virus, H7N9 Subtype / genetics
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Influenza A Virus, H7N9 Subtype / isolation & purification*
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Influenza in Birds / virology*
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Influenza, Human / diagnosis
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Influenza, Human / epidemiology*
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Influenza, Human / virology*
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Neuraminidase / genetics*
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Neuraminidase / metabolism
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Phylogeny
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Pneumonia / diagnostic imaging
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Polymerase Chain Reaction
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Poultry / virology
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Pulmonary Emphysema / diagnostic imaging
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Tomography, X-Ray Computed
Substances
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Hemagglutinin Glycoproteins, Influenza Virus
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Neuraminidase