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, 2019, 8171897

The Effect of Exercise on the Prevention of Osteoporosis and Bone Angiogenesis


The Effect of Exercise on the Prevention of Osteoporosis and Bone Angiogenesis

Xiaoyang Tong et al. Biomed Res Int.


Physical activity or appropriate exercise prevents the development of osteoporosis. However, the exact mechanism remains unclear although it is well accepted that exercise or mechanical loading regulates the hormones, cytokines, signaling pathways, and noncoding RNAs in bone. Accumulating evidence has shown that bone is a highly vascularized tissue, and dysregulation of vasculature is associated with many bone diseases such as osteoporosis or osteoarthritis. In addition, exercise or mechanical loading regulates bone vascularization in bone microenvironment via the modulation of angiogenic mediators, which play a crucial role in maintaining skeletal health. This review discusses the effects of exercise and its underlying mechanisms for osteoporosis prevention, as well as an angiogenic and osteogenic coupling in response to exercise.


Figure 1
Figure 1
The potential mechanisms of exercise in promoting osteogenesis and angiogenesis.

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    1. NIH Consensus Development Panel on Osteoporosis Prevention Diagnosis and Therapy. Osteoporosis prevention, diagnosis, and therapy. The Journal of the American Medical Association. 2001;285(6):785–795. doi: 10.1001/jama.285.6.785. - DOI - PubMed
    1. Bliuc D., Alarkawi D., Nguyen T. V., Eisman J. A., Center J. R. Risk of subsequent fractures and mortality in elderly women and men with fragility fractures with and without osteoporotic bone density: the dubbo osteoporosis epidemiology study. Journal of Bone and Mineral Research. 2015;30(4):637–646. doi: 10.1002/jbmr.2393. - DOI - PubMed
    1. Wade S. W., Strader C., Fitzpatrick L. A., Anthony M. S., O'Malley C. D. Estimating prevalence of osteoporosis: examples from industrialized countries. Archives of Osteoporosis. 2014;9:p. 182. doi: 10.1007/s11657-014-0182-3. - DOI - PubMed
    1. Cheng H., Gary L. C., Curtis J. R., et al. Estimated prevalence and patterns of presumed osteoporosis among older Americans based on Medicare data. Osteoporosis International. 2009;20(9):1507–1515. doi: 10.1007/s00198-009-0835-z. - DOI - PMC - PubMed
    1. Evans E. M., Racette S. B., Van Pelt R. E., Peterson L. R., Villareal D. T. Effects of soy protein isolate and moderate exercise on bone turnover and bone mineral density in postmenopausal women. Menopause. 2007;14(3):481–488. doi: 10.1097/01.gme.0000243570.78570.f7. - DOI - PMC - PubMed