Clinical significance of soluble adhesion molecules in anti-NMDAR encephalitis patients

Ann Clin Transl Neurol. 2019 Apr 11;6(5):945-953. doi: 10.1002/acn3.740. eCollection 2019 May.

Abstract

Increasing evidence indicates that immune system dysfunction affects anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti-NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule-1 (sICAM-1), vascular adhesion molecule-1 (sVCAM-1), and L-selectin (sL-selectin), were measured in the CSF and serum of 26 participants with anti-NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM-1, sVCAM-1 and sL-selectin were significantly elevated in the anti-NMDAR encephalitis group. sVCAM-1 levels were positively associated with modified Rankin scale score in anti-NMDAR encephalitis patients at the onset and 3-month follow-up.

MeSH terms

  • Adolescent
  • Adult
  • Anti-N-Methyl-D-Aspartate Receptor Encephalitis / physiopathology*
  • Cell Adhesion Molecules / blood*
  • E-Selectin / blood
  • Female
  • Humans
  • Intercellular Adhesion Molecule-1 / blood
  • L-Selectin / blood
  • Male
  • Middle Aged
  • Vascular Cell Adhesion Molecule-1 / blood

Substances

  • Cell Adhesion Molecules
  • E-Selectin
  • ICAM1 protein, human
  • Vascular Cell Adhesion Molecule-1
  • Intercellular Adhesion Molecule-1
  • L-Selectin

Grant support

This work was funded by National Natural Science Foundation of China grants 81673950, 81760413, and 81760902; Guangdong Provincial Science and Technology grants 2017A020215182 and 2016A020215101.