Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

Sci Transl Med. 2019 May 29;11(494):eaau9242. doi: 10.1126/scitranslmed.aau9242.


Nipah virus is an emerging pathogen in the Paramyxoviridae family. Upon transmission of Nipah virus from its natural reservoir, Pteropus spp. fruit bats, to humans, it causes respiratory and neurological disease with a case-fatality rate about 70%. Human-to-human transmission has been observed during Nipah virus outbreaks in Bangladesh and India. A therapeutic treatment for Nipah virus disease is urgently needed. Here, we tested the efficacy of remdesivir (GS-5734), a broad-acting antiviral nucleotide prodrug, against Nipah virus Bangladesh genotype in African green monkeys. Animals were inoculated with a lethal dose of Nipah virus, and a once-daily intravenous remdesivir treatment was initiated 24 hours later and continued for 12 days. Mild respiratory signs were observed in two of four treated animals, whereas all control animals developed severe respiratory disease signs. In contrast to control animals, which all succumbed to the infection, all remsdesivir-treated animals survived the lethal challenge, indicating that remdesivir represents a promising antiviral treatment for Nipah virus infection.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adenosine Monophosphate / analogs & derivatives*
  • Adenosine Monophosphate / pharmacology
  • Adenosine Monophosphate / therapeutic use
  • Alanine / analogs & derivatives*
  • Alanine / pharmacology
  • Alanine / therapeutic use
  • Animals
  • Brain / pathology
  • Brain / virology
  • Chlorocebus aethiops
  • Female
  • Henipavirus Infections / blood
  • Henipavirus Infections / drug therapy*
  • Henipavirus Infections / virology*
  • Male
  • Meningoencephalitis / drug therapy
  • Meningoencephalitis / virology
  • Neutralization Tests
  • Nipah Virus / drug effects*
  • Viremia / blood
  • Viremia / drug therapy
  • Viremia / virology
  • Virus Replication / drug effects


  • remdesivir
  • Adenosine Monophosphate
  • Alanine