The vaginal microbiome and preterm birth

Nat Med. 2019 Jun;25(6):1012-1021. doi: 10.1038/s41591-019-0450-2. Epub 2019 May 29.

Abstract

The incidence of preterm birth exceeds 10% worldwide. There are significant disparities in the frequency of preterm birth among populations within countries, and women of African ancestry disproportionately bear the burden of risk in the United States. In the present study, we report a community resource that includes 'omics' data from approximately 12,000 samples as part of the integrative Human Microbiome Project. Longitudinal analyses of 16S ribosomal RNA, metagenomic, metatranscriptomic and cytokine profiles from 45 preterm and 90 term birth controls identified harbingers of preterm birth in this cohort of women predominantly of African ancestry. Women who delivered preterm exhibited significantly lower vaginal levels of Lactobacillus crispatus and higher levels of BVAB1, Sneathia amnii, TM7-H1, a group of Prevotella species and nine additional taxa. The first representative genomes of BVAB1 and TM7-H1 are described. Preterm-birth-associated taxa were correlated with proinflammatory cytokines in vaginal fluid. These findings highlight new opportunities for assessment of the risk of preterm birth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • African Americans
  • Biodiversity
  • Cohort Studies
  • Cytokines / metabolism
  • Female
  • Host Microbial Interactions / immunology
  • Humans
  • Infant, Newborn
  • Inflammation Mediators / metabolism
  • Longitudinal Studies
  • Metagenomics
  • Microbiota* / genetics
  • Microbiota* / immunology
  • Premature Birth / etiology
  • Premature Birth / immunology
  • Premature Birth / microbiology*
  • Risk Factors
  • United States
  • Vagina / immunology
  • Vagina / microbiology*
  • Young Adult

Substances

  • Cytokines
  • Inflammation Mediators