Magnetic resonance imaging of the brain in patients with anosmia and hypothalamic hypogonadism (Kallmann's syndrome)

J Clin Endocrinol Metab. 1987 Sep;65(3):581-4. doi: 10.1210/jcem-65-3-581.


Kallmann's syndrome is characterized by hypogonadotropic hypogonadism and anosmia. Postmortem studies have revealed either hypoplasia or aplasia of the rhinencephalon, respectively, in patients with hyposmia and anosmia. This anatomical defect has now been demonstrated in vivo in four patients with Kallmann's syndrome by magnetic resonance imaging.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brain / pathology*
  • Follicle Stimulating Hormone / blood
  • Humans
  • Hypogonadism / diagnosis*
  • Hypothalamic Diseases / diagnosis*
  • Luteinizing Hormone / blood
  • Magnetic Resonance Spectroscopy*
  • Male
  • Olfaction Disorders / diagnosis*
  • Testosterone / blood


  • Testosterone
  • Luteinizing Hormone
  • Follicle Stimulating Hormone