Tm3+ -Sensitized NIR-II Fluorescent Nanocrystals for In Vivo Information Storage and Decoding

Angew Chem Int Ed Engl. 2019 Jul 22;58(30):10153-10157. doi: 10.1002/anie.201903536. Epub 2019 Jun 26.

Abstract

In vivo fluorescence imaging in the second near-infrared window (NIR-II) affords deep-tissue penetration and high spatial resolution. Herein, we present a new type of Tm3+ -sensitized lanthanide nanocrystals with both excitation (1208 nm) and emission (1525 nm) located in the NIR-II window for in vivo optical information storage and decoding. Taking advantage of the tunable fluorescence lifetimes, the optical multiplexed encoding capacity is enhanced accordingly. Micro-devices with QR codes featuring the NIR-II fluorescence-lifetime multiplexed encoding were implanted into mice and were successfully decoded through time-gated fluorescence imaging technology.

Keywords: NIR-II excitation; in vivo imaging; lanthanide-doped nanocrystals; multiplexed encoding.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Information Storage and Retrieval
  • Mice
  • Nanoparticles / chemistry*
  • Optical Imaging
  • Spectroscopy, Near-Infrared / methods
  • Thulium / chemistry*

Substances

  • Thulium