Tigecycline

Review
In: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006.
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Excerpt

Tigecycline is a tetracycline antibiotic. A number of reviews have stated that tetracyclines are contraindicated during breastfeeding because of possible staining of infants' dental enamel or bone deposition of tetracyclines. However, a close examination of available literature indicates that there is not likely to be harm in short-term use of a tigecycline during lactation because the drug is 71 to 89% bound to plasma proteins, so milk levels are likely low and absorption by the infant is inhibited by the calcium in breastmilk. Short-term use of tigecycline is acceptable in nursing mothers. As a theoretical precaution, avoid prolonged or repeat courses during nursing. Monitor the infant for rash and for possible effects on the gastrointestinal flora, such as diarrhea or candidiasis (thrush, diaper rash).

Publication types

  • Review