New phthalide derivatives from the Biscogniauxia sp. and their activities

Yan-Ying Liu; Huan Zhao; Jun Xie; Jian Zou; Dan Hu; Liang-Dong Guo; Guo-Dong Chen; Xin-Sheng Yao; Hao Gao

doi:10.1016/j.fitote.2019.104184

New phthalide derivatives from the Biscogniauxia sp. and their activities

Fitoterapia. 2019 Sep:137:104184. doi: 10.1016/j.fitote.2019.104184. Epub 2019 May 28.

Authors

Yan-Ying Liu¹, Huan Zhao², Jun Xie¹, Jian Zou¹, Dan Hu¹, Liang-Dong Guo³, Guo-Dong Chen⁴, Xin-Sheng Yao¹, Hao Gao⁵

Affiliations

¹ Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China.
² College of Traditional Chinese Medicine, Jinan University, Guangzhou 510632, People's Republic of China.
³ State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100190, People's Republic of China.
⁴ Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: chgdtong@jnu.edu.cn.
⁵ Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy/Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and Drugs Research, Jinan University, Guangzhou 510632, People's Republic of China. Electronic address: tghao@jnu.edu.cn.

PMID: 31145983
DOI: 10.1016/j.fitote.2019.104184

Abstract

Five new phthalide derivatives, biscogniphthalides A-D (1, 2, 3a/3b, and 4), were isolated from Biscogniauxia sp. (No. 69-8-7-1), along with one related known phthalide (5). Their structures were determined by comprehensive spectroscopic analyses, chemical derivatization, and quantum chemical ECD calculations. In addition, the anti-acetyl cholinesterase, antimicrobial, and anti-α-glucosidase activities of 1-5 were evaluated.

MeSH terms

Anti-Infective Agents / isolation & purification
Anti-Infective Agents / pharmacology
Benzofurans / isolation & purification
Benzofurans / pharmacology*
China
Cholinesterase Inhibitors / isolation & purification
Cholinesterase Inhibitors / pharmacology
Molecular Structure
Xylariales / chemistry*

Substances

Anti-Infective Agents
Benzofurans
Cholinesterase Inhibitors
phthalide