The Whys and Hows of Calculating Total Cellular ATP Production Rate

Megan E Handel; Martin D Brand; Shona A Mookerjee

doi:10.1016/j.tem.2019.04.007

The Whys and Hows of Calculating Total Cellular ATP Production Rate

Trends Endocrinol Metab. 2019 Jul;30(7):412-416. doi: 10.1016/j.tem.2019.04.007. Epub 2019 May 27.

Authors

Megan E Handel¹, Martin D Brand², Shona A Mookerjee³

Affiliations

¹ Touro University California College of Pharmacy, Vallejo, CA 94592, USA.
² Buck Institute for Research on Aging, Novato, CA 94945, USA.
³ Touro University California College of Pharmacy, Vallejo, CA 94592, USA; Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: Shona.Mookerjee@tu.edu.

PMID: 31147164
DOI: 10.1016/j.tem.2019.04.007

Abstract

Quantifying total cellular ATP production rate has become easier with recent technology and is essential to understanding energy metabolism in cells and tissues. We review fundamental concepts for determining total cellular ATP production rate from measurements of oxygen consumption and acidification rates and discuss their application to answering biological questions.

MeSH terms

Adenosine Triphosphate / metabolism*
Cell Differentiation / genetics
Cell Differentiation / physiology
Energy Metabolism / genetics
Energy Metabolism / physiology*
Humans
Oxygen Consumption / genetics
Oxygen Consumption / physiology*

Substances

Adenosine Triphosphate