Efficiency of sirolimus delivery to the skin is dependent on administration route and formulation

J Dermatol Sci. 2019 Jun;94(3):350-353. doi: 10.1016/j.jdermsci.2019.05.002. Epub 2019 May 13.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Cutaneous
  • Administration, Oral
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Drug Compounding / methods
  • Gels
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Immunosuppressive Agents / analysis
  • Immunosuppressive Agents / pharmacokinetics
  • Liniments / administration & dosage
  • Liniments / analysis
  • Liniments / pharmacokinetics
  • Mice, Hairless
  • Pharmaceutical Vehicles / chemistry
  • Sirolimus / administration & dosage*
  • Sirolimus / analysis
  • Sirolimus / pharmacokinetics
  • Skin / chemistry*
  • Skin Cream / administration & dosage
  • Skin Cream / analysis
  • Skin Cream / pharmacokinetics
  • Tissue Distribution
  • Tuberous Sclerosis / drug therapy
  • Tuberous Sclerosis / immunology

Substances

  • Gels
  • Immunosuppressive Agents
  • Liniments
  • Pharmaceutical Vehicles
  • Sirolimus