The Relaxant Mechanisms of Hydrogen Sulfide in Corpus Cavernosum

Methods Mol Biol. 2019;2007:137-150. doi: 10.1007/978-1-4939-9528-8_10.


In several animal and human studies, the contribution of the endothelium, nitric oxide/soluble guanosine monophosphate (NO/cGMP) pathway, adenylyl cyclase, phosphodiesterase (PDE), potassium (K+) channels, L-type calcium channels, Na+-K+-ATPase, muscarinic acetylcholine receptors, RhoA/Rho-kinase pathway, and cyclooxygenase (COX)/arachidonic acid cascade on the relaxant mechanism of L-cysteine/H2S pathway in corpus cavernosum has been investigated. In this chapter the relaxant mechanisms of H2S in corpus cavernosum is discussed with data available in the current relevant literature. Also, in vitro experimental procedure for mice corpus cavernosum which used to investigate the relaxant effect of H2S is given in detail.

Keywords: Corpus cavernosum; Erectile dysfunction; Erectile function.

MeSH terms

  • Animals
  • Endothelium, Vascular / metabolism*
  • Humans
  • Hydrogen Sulfide / metabolism*
  • Male
  • Mice
  • Penile Erection / physiology*
  • Penis / physiology*
  • Signal Transduction / physiology*


  • Hydrogen Sulfide