Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra

Mar Drugs. 2019 May 30;17(6):319. doi: 10.3390/md17060319.


So far, the Futuna Islands located in the Central Indo-Pacific Ocean have not been inventoried for their diversity in marine sponges and associated chemical diversity. As part of the Tara Pacific expedition, the first chemical investigation of the sponge Narrabeena nigra collected around the Futuna Islands yielded 18 brominated alkaloids: seven new bromotryptamine derivatives 1-7 and one new bromotyramine derivative 8 together with 10 known metabolites of both families 9-18. Their structures were deduced from extensive analyses of nuclear magnetic resonance (NMR) and high-resolution mass spectrometry (HRMS) data. In silico metabolite anticipation using the online tool MetWork revealed the presence of a key and minor biosynthetic intermediates. These 18 compounds showed almost no cytotoxic effect up to 10 µM on human neuroblastoma SH-SY5Y and microglia BV2 cells, and some of them exhibited an interesting neuroprotective activity by reducing oxidative damage.

Keywords: Bromotryptamine; Bromotyramine; Futuna; Narrabeena; Porifera; aromatic alkaloids; coral reefs; neuroprotective agents.

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / isolation & purification
  • Alkaloids / pharmacology*
  • Alkaloids / toxicity
  • Animals
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Computer Simulation
  • Humans
  • Internet
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Mice
  • Neuroprotective Agents / chemistry
  • Neuroprotective Agents / isolation & purification
  • Neuroprotective Agents / pharmacology
  • Oxidative Stress / drug effects*
  • Pacific Ocean
  • Porifera / chemistry*
  • Tropical Climate


  • Alkaloids
  • Neuroprotective Agents