The Use of Umbilical Cord Blood for Autologous Transfusion in Neonatal Open Heart Surgery

Abstract

In the last few decades, the use of umbilical cord blood (UCB) has received increasing attention, not only as a source of stem cells, but also as a transfusion product for the treatment of anemia in the neonatal and even the adult population. This review focuses on data reports and collection efforts related to the autologous transfusion of UCB in full-term neonates with prenatally diagnosed critical congenital heart defects. This review summarizes different aspects of UCB transfusion, including indications and contraindications; the collection procedure; storage timing; and special properties of one of its constituents, fetal hemoglobin, in the setting of hypothermic cardiopulmonary bypass.

Keywords: Blood conservation; Cardiopulmonary bypass; Congenital heart defects; Prenatal diagnoses; Transposition of the great arteries; Umbilical cord blood.