Lack of Gdf11 does not improve anemia or prevent the activity of RAP-536 in a mouse model of β-thalassemia

Blood. 2019 Aug 8;134(6):568-572. doi: 10.1182/blood.2019001057. Epub 2019 May 31.

Abstract

There is a Blood Commentary on this article in this issue.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Anemia / blood
  • Anemia / drug therapy
  • Anemia / etiology
  • Animals
  • Biomarkers
  • Bone Morphogenetic Proteins / deficiency*
  • Bone Morphogenetic Proteins / genetics
  • Bone Morphogenetic Proteins / metabolism
  • Disease Models, Animal
  • Growth Differentiation Factors / deficiency*
  • Growth Differentiation Factors / genetics
  • Growth Differentiation Factors / metabolism
  • Mice
  • Mice, Transgenic
  • Recombinant Fusion Proteins / pharmacology*
  • Treatment Outcome
  • beta-Thalassemia / blood
  • beta-Thalassemia / drug therapy
  • beta-Thalassemia / genetics
  • beta-Thalassemia / metabolism*

Substances

  • Biomarkers
  • Bone Morphogenetic Proteins
  • Gdf11 protein, mouse
  • Growth Differentiation Factors
  • RAP-536
  • Recombinant Fusion Proteins