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Practice Guideline
, 68 (8), 1356-1378

British Society of Gastroenterology and UK-PSC Guidelines for the Diagnosis and Management of Primary Sclerosing Cholangitis

Practice Guideline

British Society of Gastroenterology and UK-PSC Guidelines for the Diagnosis and Management of Primary Sclerosing Cholangitis

Michael Huw Chapman et al. Gut.


These guidelines on the management of primary sclerosing cholangitis (PSC) were commissioned by the British Society of Gastroenterology liver section. The guideline writing committee included medical representatives from hepatology and gastroenterology groups as well as patient representatives from PSC Support. The guidelines aim to support general physicians, gastroenterologists and surgeons in managing adults with PSC or those presenting with similar cholangiopathies which may mimic PSC, such as IgG4 sclerosing cholangitis. It also acts as a reference for patients with PSC to help them understand their own management. Quality of evidence is presented using the AGREE II format. Guidance is meant to be used as a reference rather than for rigid protocol-based care as we understand that management of patients often requires individual patient-centred considerations.

Keywords: sclerosing cholangitis.

Conflict of interest statement

Competing interests: DT – involvement in clinical trials in PSC (NGM, Takeda, Shire), funding from British Liver Trust, PSC Partners, PSC Support, EASL, SMR – Involvement in clinical trials in PSC and sits on the advisory board for FALK and Intercept. GH - medical adviser for PSC Support, speaker fees and educational support from Falk Pharma.


Figure 1
Figure 1
Algorithm for the management of suspected primary sclerosing cholangitis.
Figure 2
Figure 2
Algorithm for the investigation of possible cholangiocarcinoma in patients with primary sclerosing cholangitis.

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