Human granulocyte colony-stimulating factor produced by Escherichia coli shortens the period of granulocytopenia induced by irradiation in mice

Jpn J Cancer Res. 1987 Aug;78(8):763-6.


Daily administration of purified human granulocyte colony-stimulating factor produced by E. coli (Hu-G-CSF) accelerated the recovery from neutropenia induced by total-body irradiation in mice. Granulocyte-macrophage progenitors assayed as colony-forming unit granulocyte/macrophage (CFU-GM) in spleen were markedly increased in number by Hu-G-CSF, and the accelerated recovery from neutropenia may be due to the stimulation of granulocytopoiesis by the G-CSF from progenitor cells.

MeSH terms

  • Agranulocytosis / drug therapy*
  • Animals
  • Escherichia coli / genetics
  • Humans
  • Interleukin-3 / therapeutic use*
  • Male
  • Mice
  • Radiation Injuries, Experimental / drug therapy*
  • Time Factors


  • Interleukin-3