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. 2019 Sep;19(9):2468-2478.
doi: 10.1111/ajt.15488. Epub 2019 Jun 26.

Risk Factors for Multidrug-Resistant Organisms Among Deceased Organ Donors

Free PMC article

Risk Factors for Multidrug-Resistant Organisms Among Deceased Organ Donors

Judith A Anesi et al. Am J Transplant. .
Free PMC article


Donor infection or colonization with a multidrug-resistant organism (MDRO) affects organ utilization and recipient antibiotic management. Approaches to identifying donors at risk of carrying MDROs are unknown. We sought to determine the risk factors for MDROs among transplant donors. A multicenter retrospective cohort study was conducted at four transplant centers between 2015 and 2016. All deceased donors who donated at least one organ were included. Cultures obtained during the donor's terminal hospitalization and organ procurement were evaluated. The primary outcome was isolation of an MDRO on culture. Multivariable Cox regression was used to determine risk factors associated with time to donor MDRO. Of 440 total donors, 64 (15%) donors grew an MDRO on culture. Predictors of an MDRO on donor culture included hepatitis C viremia (hazard ratio [HR] 4.09, 95% confidence interval [CI] 1.71-9.78, P = .002), need for dialysis (HR 4.59, 95% CI 1.09-19.21, P = .037), prior hematopoietic cell transplant (HR 7.57, 95% CI 1.03-55.75, P = .047), and exposure to antibiotics with a narrow gram-negative spectrum (HR 1.13, 95% CI 1.00-1.27, P = .045). This is the first study to determine risk factors for MDROs among deceased donors and will be important for risk stratifying potential donors and informing transplant recipient prophylaxis.

Keywords: clinical research/practice; donors and donation: donor evaluation; donors and donation: donor-derived infections; epidemiology; health services and outcomes research; infection and infectious agents - bacterial; infectious disease; organ procurement and allocation.

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