MeCP2: an epigenetic regulator of critical periods

Curr Opin Neurobiol. 2019 Dec:59:95-101. doi: 10.1016/j.conb.2019.04.004. Epub 2019 Jun 1.


Complex adult behaviors arise from the integration of sequential and often overlapping critical periods (CPs) early in life and adolescence. These processes rely on a subtle interplay between the set of genes inherited from the parents, the surrounding environment and epigenetic regulation. Methyl-CpG-binding protein 2 (MeCP2) has been shown to recognize epigenetic states and regulate gene expression by reading methylated DNA. Here, we will review the recent findings revealing the role of MeCP2 during postnatal CPs of development using mouse models of Rett (RTT) syndrome.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Epigenesis, Genetic
  • Humans
  • Methyl-CpG-Binding Protein 2
  • Mice
  • Rett Syndrome*


  • Methyl-CpG-Binding Protein 2