Astrovirus and the microbiome

Curr Opin Virol. 2019 Aug:37:10-15. doi: 10.1016/j.coviro.2019.05.002. Epub 2019 Jun 1.


Although astroviruses are most commonly associated with acute gastrointestinal illness in humans, their ability to infect a broad range of hosts and cause a spectrum of disease makes them widespread and complex pathogens. The precise mechanisms that dictate the course of astrovirus disease have not been studied extensively but are likely driven by multifactorial host-microbe interactions. Recent insights from studies of animal astrovirus infections have revealed both beneficial and detrimental effects for the host. However, further in-depth studies are needed to fully explore the consequences of astrovirus-induced changes in the gut microenvironment as well as the role of the microbiota in astrovirus infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Astroviridae / pathogenicity
  • Astroviridae Infections* / immunology
  • Astroviridae Infections* / microbiology
  • Birds / microbiology
  • Birds / virology
  • Chiroptera / microbiology
  • Chiroptera / virology
  • Gastroenteritis* / immunology
  • Gastroenteritis* / microbiology
  • Gastroenteritis* / virology
  • Gastrointestinal Microbiome / immunology
  • Host Microbial Interactions
  • Humans
  • Mamastrovirus / pathogenicity*
  • Mice
  • Microbial Interactions*
  • RNA Viruses