Objective:To determine whether the preoperative results of glycerol test of electrocochleography and hearing stage have a prognostic value on the effects of endolymphatic sac decompression surgery in patients with unilateral Meniere's disease. Method:A retrospective study was conducted of 58 unilateral Meniere's disease patients who underwent endolymphatic sac decompression surgery. The correlation between the preoperative results of glycerol test of electrocochleography， hearing stage and vertigo control was analyzed by Kendall test. Result:Patients in the positive glycerol test of electrocochleography group had better vertigo control after the decompression of the lymphatic sac than the negative group(P=0.029). Preoperative hearing staging was significantly associated with vertigo control after endolymphatic sac decompression(P=0.028). The better the preoperative hearing, the higher the control rate of vertigo after endolymphatic sac decompression. The stage Ⅰ patients were 91.7%, the stage Ⅱ patients were 78.1%, and the third stage Ⅲ patients were 57.1%, respectively. Conclusion:Our findings suggested that the positive preoperative results of glycerol test of electrocochleography and better hearing stage may indicate a better effects of endolymphatic sac decompression surgery in patients with unilateral Meniere's disease.
目的:研究梅尼埃病患者甘油试验耳蜗电图（ECochG）结果及听力分期对内淋巴囊减压术的预估作用。方法:回顾性分析58例单侧梅尼埃病患者术前甘油试验ECochG及听力分期，并与术后疗效分级进行相关性分析。结果:行内淋巴囊减压术后，术前甘油试验ECochG阳性组较阴性组眩晕控制更好（P=0.029）。术前听力分期与内淋巴囊减压术后眩晕控制疗效显著相关（P=0.028），术前听力越好，内淋巴囊减压术后眩晕控制率越高，Ⅰ期患者为91.7%，Ⅱ期为78.1%，Ⅲ期为57.1%。结论:通过观察患者甘油试验ECochG的动态变化及听力分期可对患者内淋巴囊减压术的疗效进行预估评价。若患者术前ECochG的－SP/AP>0.4，应用脱水剂后－SP/AP≤0.4或－SP/AP比值较前减小≥15%，则患者内淋巴囊减压术预期获得更好疗效的可能性较大。术前听力越好，内淋巴囊减压术后眩晕控制率越高。.
Keywords: Meniere's disease; electrocochleography; endolymphatic sac decompression.
Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.