Directional non-cell autonomy and the transmission of polarity information by the frizzled gene of Drosophila

Nature. 1987 Oct;329(6139):549-51. doi: 10.1038/329549a0.


The function of the frizzled (fz) locus is required for the development of a parallel array of bristles and hairs on the adult cuticle of Drosophila melanogaster. Marked fz mitotic clones from five alleles were generated and examined in the wing. Three alleles have a non-cell-autonomous hair polarity phenotype; wild-type cells distal to fz clones produce hairs that have an abnormal polarity. In contrast, fz clones of the other two fz alleles examined do not disrupt the polarity of neighbouring cells. These data suggest that fz has two mutably separate functions in establishing hair polarity on the wing. One function involves the transmittance and/or generation of a polarity signal along the proximal-distal axis of the wing. The second function involves the cellular interpretation of a polarity signal.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alleles
  • Animals
  • Clone Cells
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / growth & development
  • Eye / anatomy & histology
  • Genes
  • Hair
  • Morphogenesis
  • Mutation
  • Skin / ultrastructure
  • Wings, Animal