Metabolic Adaptation Sets the Fate of Regulatory Macrophages

Cell Metab. 2019 Jun 4;29(6):1240-1242. doi: 10.1016/j.cmet.2019.05.012.


In this issue of Cell Metabolism, Du et al. (2019) describe how insulin-like growth factor 2 (IGF-2), a protein with structural similarity to insulin, induces an anti-inflammatory phenotype in maturing macrophages through reprogramming of their mitochondrial metabolism. These anti-inflammatory properties are maintained upon secondary stimulation and alleviate experimental autoimmune encephalomyelitis (EAE) in vivo.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Anti-Inflammatory Agents
  • Encephalomyelitis, Autoimmune, Experimental*
  • Insulin-Like Growth Factor II*
  • Macrophages
  • Oxidative Phosphorylation


  • Anti-Inflammatory Agents
  • Insulin-Like Growth Factor II