Interaction of small molecules with polynucleotide repeats and frameshift site RNA

Arch Pharm (Weinheim). 2019 Aug;352(8):e1900062. doi: 10.1002/ardp.201900062. Epub 2019 Jun 6.

Abstract

This mini-review describes the interaction between small molecules and RNA, in addition to its application either in treating RNA-associated diseases or detecting target molecules. In the case of RNA-associated disease treatment, the designed small molecules interact with RNA sites, forming adducts and providing successful therapeutic strategies over oligonucleotides. On the other hand, synthetically designed RNA moieties (aptamers) interact with target molecules like toxins, drugs, hormones; these interactions are useful in the detection, quantification or separation of these target moieties.

Keywords: AIDS; ALS; DM1; FTD; FXTAS; RNA; RNA-associated diseases; aptamers; interaction; small molecules.

Publication types

  • Review

MeSH terms

  • Aptamers, Nucleotide / chemical synthesis
  • Aptamers, Nucleotide / chemistry
  • Hormones / analysis
  • Pharmaceutical Preparations / analysis
  • Polynucleotides / chemistry*
  • RNA / chemistry*
  • Small Molecule Libraries / chemistry*
  • Toxins, Biological / analysis

Substances

  • Aptamers, Nucleotide
  • Hormones
  • Pharmaceutical Preparations
  • Polynucleotides
  • Small Molecule Libraries
  • Toxins, Biological
  • RNA