Second generation antihistamines: an update

Curr Opin Allergy Clin Immunol. 2019 Aug;19(4):358-364. doi: 10.1097/ACI.0000000000000556.


Purpose of review: This article presents an update on the clinical pharmacology, mechanisms of action, and safety of second generation antihistamines (SGAHs).

Recent findings: Recent research has shown the efficacy and good tolerance of SGAHs supporting its indication as first line medications for the treatment of allergic rhinoconjunctivitis and urticaria.

Summary: The information contained in this review is relevant for the correct utilization of SGAHs by practicing physicians who take care of these highly prevalent clinical disorders.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Allergic Agents / therapeutic use*
  • Conjunctivitis, Allergic / drug therapy*
  • Conjunctivitis, Allergic / epidemiology
  • Drug Utilization
  • Histamine H1 Antagonists, Non-Sedating / therapeutic use*
  • Humans
  • Practice Guidelines as Topic
  • Practice Patterns, Physicians'
  • Rhinitis, Allergic / drug therapy*
  • Rhinitis, Allergic / epidemiology
  • Spain / epidemiology


  • Anti-Allergic Agents
  • Histamine H1 Antagonists, Non-Sedating