Radiomics Signature on 3T Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Estrogen Receptor-Positive Invasive Breast Cancers: Preliminary Results for Correlation With Oncotype DX Recurrence Scores

Medicine (Baltimore). 2019 Jun;98(23):e15871. doi: 10.1097/MD.0000000000015871.


To evaluate the ability of a radiomics signature based on 3T dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) to distinguish between low and non-low Oncotype DX (OD) risk groups in estrogen receptor (ER)-positive invasive breast cancers.Between May 2011 and March 2016, 67 women with ER-positive invasive breast cancer who performed preoperative 3T MRI and OD assay were included. We divided the patients into low (OD recurrence score [RS] <18) and non-low risk (RS ≥18) groups. Extracted radiomics features included 8 morphological, 76 histogram-based, and 72 higher-order texture features. A radiomics signature (Rad-score) was generated using the least absolute shrinkage and selection operator (LASSO). Univariate and multivariate logistic regression analyses were performed to investigate the association between clinicopathologic factors, MRI findings, and the Rad-score with OD risk groups, and the areas under the receiver operating characteristic curves (AUC) were used to assess classification performance of the Rad-score.The Rad-score was constructed for each tumor by extracting 10 (6.3%) from 158 radiomics features. A higher Rad-score (odds ratio [OR], 65.209; P <.001), Ki-67 expression (OR, 17.462; P = .007), and high p53 (OR = 8.449; P = .077) were associated with non-low OD risk. The Rad-score classified low and non-low OD risk with an AUC of 0.759.The Rad-score showed the potential for discrimination between low and non-low OD risk groups in patients with ER-positive invasive breast cancers.

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Breast Neoplasms / diagnostic imaging*
  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology
  • Contrast Media / administration & dosage
  • Female
  • Gene Expression Profiling / methods
  • Gene Expression Profiling / standards
  • Genomics / methods*
  • Humans
  • Image Processing, Computer-Assisted / methods*
  • Magnetic Resonance Imaging / methods*
  • Middle Aged
  • Neoplasm Recurrence, Local / genetics
  • Neoplasm Recurrence, Local / pathology
  • Organometallic Compounds / administration & dosage
  • ROC Curve
  • Receptors, Estrogen / biosynthesis*
  • Reproducibility of Results
  • Risk Assessment
  • Sensitivity and Specificity


  • Contrast Media
  • Organometallic Compounds
  • Receptors, Estrogen
  • gadobutrol