Effect of pregabalin for the treatment of chronic refractory cough: A case report

Medicine (Baltimore). 2019 Jun;98(23):e15916. doi: 10.1097/MD.0000000000015916.


Rationale: Chronic refractory cough (CRC) is a common clinical problem which is more likely associated with some physical problems. Although many patients have received satisfactory treatment, there were still many patients suffered from long-term cough symptoms after standardized treatment.

Patient concerns: A patient suffered from postherpetic neuralgia (PHN) and also he complained CRC for more than 20 years.

Diagnosis: The patient was diagnosed with PHN and CRC.

Interventions: Pregabalin was originally administered to treat PHN.

Outcomes: pregabalin not only alleviated her pain of PHN but also relieved chronic cough.

Lessons: This report demonstrated the surprising effect of pregabalin on the treatment of CRC.

Publication types

  • Case Reports

MeSH terms

  • Analgesics / therapeutic use*
  • Chronic Disease
  • Cough / drug therapy*
  • Cough / etiology
  • Female
  • Humans
  • Middle Aged
  • Neuralgia, Postherpetic / complications*
  • Pregabalin / therapeutic use*
  • Treatment Outcome


  • Analgesics
  • Pregabalin