Internal model recalibration does not deteriorate with age while motor adaptation does

Abstract

A wide range of motor function declines with aging. Motor adaptation, which occurs when participants learn to reach accurately to a target despite a perturbation, does not deviate from this rule. There are currently 3 major hypotheses that have been put forward to explain this age-related decline in adaptation: deterioration of internal model recalibration due to age-related cerebellar degeneration, impairment of the cognitive component of motor adaptation, and deficit in the retention of the learned movement. In the present study, we systematically investigated these 3 hypotheses in a large sample of older women and men. We demonstrate that age-related deficits in motor adaptation are not due to impaired internal model recalibration or impaired retention of motor memory. Rather, we found that the cognitive component was reduced in older people. Therefore, our study suggests the interesting possibility that cerebellar-based mechanisms do not deteriorate with age despite cerebellar degeneration. In contrast, internal model recalibration appears to compensate for deficits in the cognitive component of this type of learning.

Keywords: Aging; Cerebellum; Internal model; Motor adaptation; Motor learning.