Complement C3 inhibition by compstatin Cp40 prevents intra- and extravascular hemolysis of red blood cells

Affiliations

• ¹ Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
• ² Department of Hematology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
• ³ Department of Immunohematology Diagnostics, Sanquin Diagnostic Services, Amsterdam, the Netherlands.
• ⁴ Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
• ⁵ Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland.
• ⁶ Center for Clinical Transfusion Research, Sanquin Research, Leiden, the Netherlands.
• ⁷ Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
• ⁸ Sanquin Research, Department of Immunopathology, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands s.s.zeerleder@amc.uva.nl.
• ⁹ Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
• ¹⁰ Department for BioMedical Research, University of Bern, Bern, Switzerland.